There is much to admire in this book. It is written in a pleasingly straightforward style, and offers insight on a wide range of important issues.

A decade after the completion of the Human Genome Project, the widespread appeal of personalized genomic medicine's vision and potential virtues for health care remains compelling. Advocates argue that our current medical regime “is in crisis as it is expensive, reactive, inefficient, and focused largely on one size fits all treatments for events of late stage disease.” What is revolutionary about this kind of medicine, its advocates maintain, is that it promises to resolve that crisis by simultaneously increasing the ability (...) to be “personalized,” “predictive,” “preventive,” and “participatory.” Some call personalized genomic medicine “P4 Medicine,” inscribing these cardinal virtues into the movement's name. All of these putative virtues have interesting implications for the future of health care. In this essay, we are especially interested in the claims that personalized medicine will lead to a more “participatory” or “patient‐centered” approach to health care, in which patients are “empowered” to take more personal control over their care. The rhetoric of patient empowerment is nothing new in health care, but personalized medicine is an interesting case study because it portrays empowerment as one of its key virtues and as a mechanism for fixing the health care “crisis.”. (shrink)

The extended-mind thesis says that mental states can extend beyond one’s skin. Clark and Chalmers infer from this that the subjects of such states also extend beyond their skin: the extended-self thesis. The paper asks what exactly the extended-self thesis says, whether it really does follow from the extended-mind thesis, and what it would mean if it were true. It concludes that the extended-self thesis is unattractive, and does not follow from the extended mind unless thinking beings are literally bundles (...) of mental states. (shrink)

In 2015, a flourish of “alarums and excursions” by the scientific community propelled CRISPR/Cas9 and other new gene-editing techniques into public attention. At issue were two kinds of potential gene-editing experiments in humans: those making inheritable germ-line modifications and those designed to enhance human traits beyond what is necessary for health and healing. The scientific consensus seemed to be that while research to develop safe and effective human gene editing should continue, society's moral uncertainties about these two kinds of experiments (...) needed to be better resolved before clinical trials of either type should be attempted. In the United States, the National Academies of Science, Engineering and Medicine convened the Committee on Human Gene Editing: Scientific, Medical and Ethical Considerations to pursue that resolution. The committee's 2017 consensus report has been widely interpreted as “opening the door” to inheritable human genetic modification and holding a line against enhancement interventions. But on a close reading it does neither. There are two reasons for this eccentric conclusion, both of which depend upon the strength of the committee's commitment to engaging diverse public voices in the gene-editing policy-making process. (shrink)

According to a view attractive to both metaphysicians and ethicists, every period in a person’s life is the life of a being just like that person except that it exists only during that period. These “subpeople” appear to have moral status, and their interests seem to clash with ours: though it may be in some person’s interests to sacrifice for tomorrow, it is not in the interests of a subperson coinciding with him only today, who will never benefit from it. (...) Or perhaps there is no clash, and a subperson’s interests derive from those of the person it coincides with. But this makes it likely that our own interests derive from those of other beings coinciding with us. (shrink)

This paper is about the neglected question of what sort of things we are metaphysically speaking. It is different from the mind-body problem and from familiar questions of personal identity. After explaining what the question means and how it differs from others, the paper tries to show how difficult it is to give a satisfying answer.

What is a temporal part? Most accounts explain it in terms of timeless parthood: a thing's having a part without temporal qualification. Some find this hard to understand, and thus find the view that persisting things have temporal parts--fourdimensionalism--unintelligible. T. Sider offers to help by defining temporal parthood in terms of a thing's having a part at a time. I argue that no such account can capture the notion of a temporal part that figures in orthodox four-dimensionalism: temporal parts must (...) be timeless parts. This enables us to state four-dimensionalism more clearly. (shrink)

In The Human Animal I argued that we are animals, and that those animals do not persist by virtue of any sort of psychological continuity. Rather, personal identity in this sense consists in having the same biological life. And I said that a human life requires a functioning brainstem. Rina Tzinman takes this and other remarks to imply that personal identity consists in the continued functioning of the brainstem, which looks clearly false. I say it doesn’t follow. But Alan Shewmon (...) appears to have refuted my claim about the brainstem. (shrink)

Expectations are high around the world that more research on human genomic variation will improve the utility of “precision medicine” and help address population health disparities through “precision public health”. In large measure, these expectations rest on the premise that researchers will be able to share human DNA samples and genomic data freely and widely across the international scientific community. The human genomics community pioneered polices of early deposit of genomic research data into open databases to facilitate the exchange and (...) use of data during the mapping and sequencing of the human genome in the 1990s, and the success of those policies has made a... (shrink)

Personal identity deals with questions about ourselves qua people (or persons). Many of these questions are familiar ones that occur to everyone at some time: What am I? When did I begin? What will happen to me when I die? Discussions of personal identity go right back to the origins of Western philosophy, and most major figures have had something to say about it. (There is also a rich literature on personal identity in Eastern philosophy, which I am not competent (...) to discuss. Collins 1982 is a good source.). (shrink)

This chapter contains sections titled: The Problems of Personal Identity Understanding the Persistence Question Accounts of Our Identity Through Time The Psychological Approach The Fission Problem The Problem of the Thinking Animal The Somatic Approach Conclusion.

From the time of Locke, discussions of personal identity have often ignored the question of our basic metaphysical nature: whether we human people are biological organisms, spatial or temporal parts of organisms, bundles of perceptions, or what have you. The result of this neglect has been centuries of wild proposals and clashing intuitions. What Are We? is the first general study of this important question. It beings by explaining what the question means and how it differs from others, such as (...) questions of personal identity and the mind-body problem. It then examines in some depth the main possible accounts of our metaphysical nature, detailing both their theoretical virtues and the often grave difficulties they face. The book does not endorse any particular account of what we are, but argues that the matter turns on more general issues in the ontology of material things. If composition is universal--if any material things whatever make up something bigger--then we are temporal parts of organisms. If things never compose anything bigger, so that there are only mereological simples, then we too are simples--perhaps the immaterial substances of Descartes--or else we do not exist at all (a view Olson takes very seriously). The intermediate view that some things compose bigger things and others do not leads almost inevitably to the conclusion that we are organisms. So we can discover what we are by working out when composition occurs. (shrink)

We are material things of a specific sort: animals of the primate species Homo sapiens. This is the view known as animalism. The most common reason for rejecting animalism is that it is has unattractive consequences about what it takes for philosophers to persist through time. If human animals are animals essentially, then our being animals implies that we are animals essentially. If they are animals accidentally, then animalism implies that we are animals only accidentally. Aristotelians say that an animal (...) is a compound of matter and form. Animalists accept the indisputable fact that we have important features not shared by any nonhuman organisms that we know of: the capacity for sophisticated rational thought, for instance, and to speak a language with a complex grammatical structure. Since animals are bodies, it follows that people are not animals. Animals, even human animals, cannot have life after death. (shrink)

Eric T. Morton ABSTRACT: Robert Talisse and Scott Aikin have argued that substantive versions of value pluralism are incompatible with pragmatism, and that all such versions of pluralism must necessarily collapse into versions of strong metaphysical pluralism. They also argue that any strong version of value pluralism is incompatible with pragmatism’s meliorist commitment and will...

The prosaic content of these sayings is that events change from future to present and from present to past. Your next birthday is in the future, but with the passage of time it draws nearer and nearer until it is present. 24 hours later it will be in the past, and then lapse forever deeper into history. And things get older: even if they don’t wear out or lose their hair or change in any other way, their chronological age is (...) always increasing. These changes are universal and inescapable: no event could ever fail to be first future, then present, then past, and no persisting thing can avoid growing older. We call this process time’s passage. (shrink)

It is often said that the same particles can simultaneously make up two or more material objects that differ in kind and in their mental, biological and other qualitative properties. Others wonder how objects made of the same parts in the same arrangement and surroundings could differ in these ways. I clarify this worry and show that attempts to dismiss or solve it miss its point. At most one can argue that it is a problem we can live with.

The view that we are human animals, " animalism ", is deeply unpopular. This paper explains what that claim says and why it is so contentious. It then argues that those who deny it face an awkward choice. They must either deny that there are any human animals, deny that human animals can think, or deny that we are the thinking things located where we are.

In lieu of an abstract, here is a brief excerpt of the content:The Human Genome Project and BioethicsEric T. Juengst, Ph.D. (bio)The fifteen-year "human genome project" at the National Institutes of Health and the Department of Energy officially began on October 1, 1990. With it began a new dimension in federally supported scientific research: concurrent funding for work to anticipate the social consequences of the project's research and to develop policies to guide the use of the knowledge it produces. As (...) a result, the National Center for Human Genome Research (NCHGR) at NIH will support the largest public investment in bioethical analysis to date.NCHGR was established to work with other federal, private, and international organizations on the scientific effort to characterize the form and content of the human genome. The research will yield information—high-resolution genetic linkage and physical maps of all the human chromosomes as well as human DNA sequence data—that will be a resource for studies of gene structure and function. It will greatly increase our understanding of the genetic aspects of human health and disease. That increased understanding will eventually provide insights into the prevention and treatment of the 3,000 known inherited disorders, and of conditions caused by our (gene-governed) physiological reactions to pathogens, toxins, and mutagens of external origin.It has been clear since the conception of the human genome project, however, that professional and public deliberations concerning the responsible use of genetic information must be a part of the process. The most immediate consequence of genome research will be the development of new diagnostic and predictive tests, well in advance of corresponding therapeutic or curative advances. The implications of acquiring and using that knowledge about individuals raise policy questions at many levels within society. The primary purpose of the Ethical, Legal and Social Implications Program at the NCHGR is to anticipate and address these questions early in the life of the scientific project, to help optimize the [End Page 71] benefits to human welfare and opportunity from the new knowledge, and to guard against its misuses.The program has identified three sets of questions as particularly important to pursue as the genome initiative proceeds:1.Issues involved in the integration of new genetic tests into medical practice. Human genome research is expected to increase greatly the number of gene-based diagnostic and prognostic tests available to health professionals. The bioethical policy problems involved in integrating those tests effectively into medical practice include developing standards for:— accuracy and quality control of genetic tests;— medical indications for testing and design of testing protocols;— professional responsibilities of clinicians who perform tests;— confidentiality of information obtained from testing;— access to and use of test results by third parties, such as health insurers; and— reimbursement for testing and test-related counseling.These are problems for both those charged with regulating the use of new genetic tests and for those establishing the standards of practice within the health professions. Thus, in addition to soliciting and funding scholarly research proposals on both the factual and normative questions raised by these problems, the program is commissioning a major new study by the National Academy of Sciences/Institute of Medicine aimed at providing professional guidelines for the integration of genetic services into mainstream medical practice.2. Issues involved in educating and counseling individuals about genetic test results. The primary risk that health professionals will face in using genetic tests is the misinterpretation of their findings and the resulting potential for psychological trauma, stigmatization, and discrimination. Sometimes, out of ignorance, patients, families, and social institutions already stigmatize genetic disorders and treat those with them unfairly. This risk broadens as the genetic elements of more health problems are uncovered and gene-based tests for susceptibilities and carrier states are developed.To protect against these risks, NCHGR is soliciting and supporting projects aimed at improving professional and public understanding of these tests and their implications. For example, a philosopher is leading a team of geneticists and physicians in a scholarly effort to clarify [End Page 72] concepts of genetic susceptibility and draw out the social meaning of their different interpretations. Other projects involve social scientific studies of genetic risk perceptions, stigmatization, and discrimination. The conclusions of these studies, and... (shrink)

In discussions of the ethics of human gene therapy, it has become standard to draw a distinction between the use of human gene transfer techniques to treat health problems and their use to enhance or improve normal human traits. Some dispute the normative force of this distinction by arguing that it is undercut by the legitimate medical use of human gene transfer techniques to prevent disease - such as genetic engineering to bolster immune function, improve the efficiency of DNA repair, (...) or add cellular receptors to capture and process cholesterol. If disease prevention is a proper goal of medicine, these critics argue, and the use of gene transfer techniques to enhance human health maintenance capacities will help achieve that goal, then the “treatment/enhancement‘ distinction cannot define the limits of legitimate gene therapy. In this paper, I argue that a line can be drawn between prevention and enhancement for gene therapy (and thus between properly medical and nonmedical uses of gene therapy), but only if one is willing to accept two rather old-fashioned claims: 1) Some health problems are best understood as if they were entities in their own right, reifiable as processes or parts in a biological system, with at least as much ontological objectivity and theoretical significance as the functions that they inhibit. 2) Legitimate preventive genetic health care should be limited to efforts to defend people from attack by these more robust pathological entities, rather than changing their bodies to evade social injustices. (shrink)

It is often said that the same particles can simultaneously make up two or more material objects that differ in kind and in their mental, biological, and other qualitative properties. Others wonder how objects made of the same parts in the same arrangement and surroundings could differ in these ways. I clarify this worry and show that attempts to dismiss or solve it miss its point. At most one can argue that it is a problem we can live with.

Trust me: my chair isn't big enough for two. You may doubt that every rational, conscious being is a person; perhaps there are beings that mistakenly believe themselves to be people. If so, read ‘rational, conscious being’ or the like for 'person'.

The Standard View of personal identity says that someone who exists now can exist at another time only if there is continuity of her mental contents or capacities. But no person is psychologically continuous with a fetus, for a fetus, at least early in its career, has no mental features at all. So the Standard View entails that no person was ever a fetus--contrary to the popular assumption that an unthinking fetus is a potential person. It is also mysterious what (...) does ordinarily happen to a human fetus, if it does not come to be a person. Although an extremely complex variant of the Standard View may allow one to persist without psychological continuity before one becomes a person but not afterwards, a far simpler solution is to accept a radically non-psychological account of our identity. (shrink)

The Standard View of personal identity says that someone who exists now can exist at another time only if there is continuity of her mental contents or capacities. But no person is psychologically continuous with a fetus, for a fetus, at least early in its career. has no mental features at all. So the Standard View entails that no person was ever a fetus---contrary to the popular assumption that an unthinking fetus is a potential person. It is also mysterious what (...) does ordinarily happen to a human fetus, if it does not come to be a person. Although an extremely complex variant of the Standard View may allow one to persist without psychological continuity before one becomes a person but not afterwards, a far simpler solution is to accept a radically non-psychological account of our identity. (shrink)

One of the main problems of personal identity is supposed to be how we relate to our bodies. A few philosophers endorse what is called a 'bodily criterion of personal identity': they say that we are our bodies, or at any rate that our identity over time consists in the identity of our bodies. Many more deny this--typically on the grounds that we can imagine ourselves coming apart from our bodies. But both sides agree that the bodily criterion is an (...) important view which anyone thinking about personal identity must consider. (shrink)

The apparent fact that each of us coincides with a thinking animal looks like a strong argument for our being animals (animalism). Some critics, however, claim that this sort of reasoning actually undermines animalism. According to them, the apparent fact that each human animal coincides with a thinking body that is not an animal is an equally strong argument for our not being animals. I argue that the critics' case fails for reasons that do not affect the case for animalism.

Philosophers often talk as if what it takes for a person to persist through time were up to us, as individuals or as a linguistic community, to decide. In most ordinary situations it might be fully determinate whether someone has survived or perished: barring some unforeseen catastrophe, it is clear enough that you will still exist ten minutes from now, for example. But there is no shortage of actual and imaginary situations where it is not so clear whether one survives. (...) Here reasonable people may disagree. There are "fission" cases where each of one's cerebral hemispheres is transplanted into a different head; Star-Trek-style "teletransportation" stories; actual cases of brain damage so severe that one can never again regain consciousness, even though one's circulation, breathing, digestion, and other "animal" functions continue; and stories where one's brain cells are gradually removed and replaced by cells from someone else, to name only a few favorites. (shrink)

Conjoined twinning is said to show that the number of human people—the number of us—can differ from the number of human organisms, and hence that we are not organisms. The paper shows that these arguments either assume the point at issue, rely on dubious and undefended assumptions, or add nothing to more familiar arguments for the same conclusion.

In this essay I explore the idea that the solution to some important problems of personal identity lies in the philosophy of language: more precisely in the nature of first-person reference. I will argue that the “linguistic solution” is at best partly successful.

Many philosophers say that time involves a kind of passage that distinguishes it from space. A traditional objection is that this passage would have to occur at some rate, yet we cannot say what the rate would be. The paper argues that the real problem with time’s passage is different: time would have to pass at one second per second, yet this is not a rate of change. This appears to refute decisively not only the view that time passes, but (...) any tensed theory of time. (shrink)

Over the last decade, more U.S. taxpayers money has been spent trying to anticipate and address the bioethical issues raised by advances in human genetics than any other set of issues in the field. Does this make sense? Not everyone in bioethics thinks so. Some think there are more important topics, like issues of health care justice, that will be neglected if the field continues to follow the money to dwell on the moral challenges of a relatively small community of (...) research scientists. Others decry genetic exceptionalism as inappropriately singling out this scientific enterprise for criticism and regulation, when the same issues are faced even more acutely in other parts of the biomedical world. Human genetics is not accelerating as fast as pharmacology, for example, or as easy to abuse as virology, or as philosophically challenging as neurology. (shrink)

Simon Cushing conducted the following interview with Eric Olson on 1 July 2016.

ABSTRACTMany philosophers say that the nature of personal identity has to do with narratives: the stories we tell about ourselves. While different narrativists address different questions of personal identity, some propose narrativist accounts of personal identity over time. The paper argues that such accounts have troubling consequences about the beginning and end of our lives, lead to inconsistencies, and involve backwards causation. The problems can be solved, but only by modifying the accounts in ways that deprive them of their appeal.

Machiavelli’s The Prince is an important modern work of political science, but it is also one that has been often misinterpreted by students and scholars. This work helps the reader to better understand Machiavelli’s consequentialism and realism by using examples from modern films and television series to illustrate his messages.

The Epicurean view is that there is nothing bad about death, and we are wrong to loathe it. This paper distinguishes several different such views, and shows that while some of them really would undermine our loathing of death, others would not. It then argues that any version that did so could be at best vacuously true: If there is nothing bad about death, that can only be because there is nothing bad about anything.

It seems evident that things sometimes get bigger by acquiring new parts. But there is an ancient argument purporting to show that this is impossible: the paradox of increase or growing argument.i Here is a sketch of the paradox. Suppose we have an object, A, and we want to make it bigger by adding a part, B. That is, we want to bring it about that A first lacks and then has B as a part. Imagine, then, that we conjoin (...) B to A in some appropriate way. Never mind what A and B are, or what this conjoining amounts to: let A be anything that can gain a part if anything can gain a part, and let B be the sort of thing that can become a part of A, and suppose we do whatever it would take to make B come to be a part of A if this is possible at all. Have we thereby made B a part of A? It seems not. We seem only to have brought it about that B is attached to A, like this. (shrink)

Because there is no agreed use of the term 'self', or characteristic features or even paradigm cases of selves, there is no idea of "the self" to figure in philosophical problems. The term leads to troubles otherwise avoidable; and because legitimate discussions under the heading of 'self' are really about other things, it is gratuitous. I propose that we stop speaking of selves.

Richard Swinburne argues that if my cerebral hemispheres were each transplanted into a different head, what would happen to me is not determined by my material parts, and I must therefore have an immaterial part. The paper argues that this argument relies on modal claims that Swinburne has not established. And the means he proposes for establishing such claims cannot succeed.

Sydney Shoemaker argues that the functionalist theory of mind entails a psychological-continuity view of personal identity, as well as providing a defense of that view against a crucial objection. I show that his view has surprising consequences, e.g. that no organism could have mental properties and that a thing's mental properties fail to supervene even weakly on its microstructure and surroundings. I then argue that the view founders on "fission" cases and rules out our being material things. Functionalism tells us (...) little if anything about personal identity. (shrink)

It is widely held that every person is a person essentially, where being a person is having special mental properties such as intelligence and self-consciousness. It follows that nothing can acquire or lose these properties. The paper argues that this rules out all familiar psychological-continuity views of personal identity over time. It also faces grave difficulties in accounting for the mental powers of human beings who are not intelligent and self-conscious, such as foetuses and those with dementia.

Accounts of personal identity over time are supposed to fall into two broad categories: 'complex views' saying that our persistence consists in something else, and 'simple views' saying that it doesn' t. But it is impossible to characterize this distinction in any satisfactory way. The debate has been systematically misdescribed. After arguing for this claim, the paper says something about how the debate might be better characterized.